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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF7
All Species:
12.42
Human Site:
T646
Identified Species:
30.37
UniProt:
Q14155
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14155
NP_001106983.1
803
90012
T646
G
P
L
E
P
P
K
T
P
K
P
W
S
L
S
Chimpanzee
Pan troglodytes
XP_509742
901
100045
T723
G
P
L
E
P
P
K
T
P
K
P
W
S
L
S
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
K621
Y
I
L
K
E
S
S
K
S
P
K
T
M
K
K
Dog
Lupus familis
XP_542671
952
105982
T715
G
P
L
E
P
P
K
T
P
K
P
W
S
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9ES28
862
97037
S682
E
E
F
A
V
R
K
S
T
A
A
L
E
E
D
Rat
Rattus norvegicus
O55043
646
73122
Y491
R
P
S
A
A
L
C
Y
K
E
D
L
S
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
S616
S
Y
I
L
K
D
S
S
K
S
P
K
T
M
K
Chicken
Gallus gallus
Q5ZLR6
764
85889
K609
Y
I
L
K
D
S
S
K
S
P
K
T
M
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001116707
858
96627
E648
S
A
A
L
C
Y
K
E
D
L
S
K
S
P
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
P425
G
L
C
G
S
P
P
P
V
P
P
A
A
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
54.9
73.3
N.A.
85
66.3
N.A.
57
56.5
N.A.
69.6
N.A.
N.A.
N.A.
N.A.
30.8
Protein Similarity:
100
81.9
70.8
77
N.A.
87.8
71.1
N.A.
72.9
72.7
N.A.
79.8
N.A.
N.A.
N.A.
N.A.
45.2
P-Site Identity:
100
100
6.6
100
N.A.
6.6
20
N.A.
6.6
6.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
13.3
100
N.A.
13.3
26.6
N.A.
33.3
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
20
10
0
0
0
0
10
10
10
10
0
0
% A
% Cys:
0
0
10
0
10
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
10
0
0
10
0
10
0
0
0
10
% D
% Glu:
10
10
0
30
10
0
0
10
0
10
0
0
10
10
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
40
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
20
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
20
10
0
50
20
20
30
20
20
0
20
50
% K
% Leu:
0
10
50
20
0
10
0
0
0
10
0
20
0
30
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
20
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
40
0
0
30
40
10
10
30
30
50
0
0
10
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% R
% Ser:
20
0
10
0
10
20
30
20
20
10
10
0
50
0
40
% S
% Thr:
0
0
0
0
0
0
0
30
10
0
0
20
10
0
0
% T
% Val:
0
0
0
0
10
0
0
0
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
30
0
0
0
% W
% Tyr:
20
10
0
0
0
10
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _